![]() The histological and neurobehavioral outcomes were assessed at acute (1 day) or subacute (7 days) stages after reperfusion. after the ischemia) alone, with both of these treatments (combination), or with vehicle. ![]() ![]() Mice subjected to 2-h filamental middle cerebral artery (MCA) occlusion were treated with NBO (95% O 2, during the ischemia) alone, with cilostazol (3 mg/kg i.p. Here, we evaluated the potential neuroprotective effects of combination treatment with NBO and cilostazol against acute and subacute brain injuries after simulated stroke. Normobaric hyperoxia (NBO) and cilostazol (6-3,4-dihydro-2-(1 H)-quinolinone) (a selective inhibitor of phosphodiesterase 3) have each been reported to exert neuroprotective effects against acute brain injury after cerebral ischemia in rodents.
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